Amiloride hydrochloride dihydrate ( MK870; MK-870; MK 870; Amiloride Hydrochloride )

Catalog No. M12644 CAS No. 17440-83-4

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Product Name

Amiloride hydrochloride dihydrate
Note

Research use only, not for human use.
Brief Description

A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
Description

A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss.
Synonyms

MK870; MK-870; MK 870; Amiloride Hydrochloride
Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

Amiloride-sensitive sodium channel
Research Area

Cardiovascular Disease
Indication

——

CAS Number

17440-83-4
Formula Weight

302.12
Molecular Formula

C6H8ClN7O·HCl·2H2O
Purity

>98%(HPLC)
Solubility

DMSO: 60 mg/mL (198.59 mM)
SMILES

C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl
Chemical Name

3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride

1.Kelly O, et al. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1279-90.

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